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Urolithiasis, or urolithiasis, is one of the pathologies of the kidneys associated with a violation of the metabolic process (metabolism) in the body. The disease has no age restrictions; it can be found in both newborns and adults. Initially, microliths ("sand") are formed, from which stones are later formed. By themselves, kidney stones rarely cause concern to the patient. Severe clinical manifestations occur when stones migrate into the ureter, causing blockage. As a result, the flow of urine from the kidney is disturbed, and severe pain occurs (renal colic). PPA advances its mission through grassroots advocacy (encouraging members to get engaged in legislative advocacy) and by promoting awareness of optimal medication therapy with all health care professionals by coordinating an effective communication network.

Features of the course of urolithiasis in women and men: 

This situation can cause acute, life-threatening kidney inflammation or impairment of its function. In such cases, the patient requires urgent surgical intervention. It is very important to treat the disease at the onset stage: this will avoid complications and bring the body back to normal in a short time.

The risk group includes people aged 20 to 55 years. The largest incidence rate is observed in the countries of Asia Minor. Urolithiasis in men is diagnosed three times more often than in women. Nevertheless, it is women who tend to form coral-shaped spiked stones, which cause many painful symptoms.

Symptoms in both sexes are almost the same. The main difference is that in men, pain in renal colic radiates to the penis, and in women, to the labia. Quite rarely (only in 17% of cases) there are diseases of a bilateral nature, that is, the formation of stones in both kidneys. 

As soon as the first signs of urolithiasis appear, you should immediately consult a doctor. In order to correctly determine how to treat urolithiasis, it is necessary first of all to identify the causes of this disease.


There are various ways we accomplish our advocacy mission:

Grassroots Action: PPA promotes a grassroots approach to promoting pediatric-friendly legislation in the US Congress. We have encouraged our members to support the following federal level laws and regulations:

  1. The Pharmaceutical Quality, Security, and Accountability Act (S. 959)
  2. Food and Drug Administration Safety and Innovation Act (FDASIA)  
  3. A general blood test and biochemistry are mandatory procedures for detecting inflammatory processes (leukocyte levels) and pathological changes in the structure of organs itself. General urine analysis - allows you to determine the chemical composition of impurities contained in urine. Ultrasound examination is the most common method that has a minimal negative effect, therefore it is not contraindicated even for pregnant women. This method allows you to detect even small formations. Excretory urography - X-ray imaging of the urinary system. In the human body, specific stones can form, which are not an obstacle to X-rays and therefore cannot be diagnosed by this method. Computed tomography is a three-dimensional image that allows you to get the most complete information about the presence of foreign bodies. It is one of the most advanced diagnostic methods.
  4. Drug Shortages Prevention Act
  5. Preserving Access to Life Saving Medications Act
  6. The Federal 340B Drug Pricing Program
  7. SCHIP: State Children's Health Insurance Program

Partnerships. PPA promotes pediatric patient safety by partnering and collaborating with other non-profit organizations, professional associations, and governmental agencies. 

American Academy of Pediatrics
International Campaign for Better Medicine
World Health Organization (WHO) "Make Medicine Children's Size" Campaign

Food and Drug Administration (FDA) Pharmacy Compounding Advisory Committee  
Patient Access to Pharmacists’ Care Coalition (PAPCC) 

Outreach Programs. PPA promotes pediatric patient safety by providing quality information to patients, parents, and the general public. a site for parents and kids!

Special Interest Groups. Unlike anything available to pediatric pharmacists today, our SIGs offer you a chance to communicate to a highly specialized audience of your choosing. Go to your MyPPAG page for more information

The Journal of Pediatric Pharmacology and Therapeutics. The JPPT is a peer-reviewed clinical medical journal dedicated to the dissemination of information regarding the safe and effective use of medications in neonates, infants, children, and adolescents. By contributing to the medical literature the JPPT plays a vital role in advancing PPA's advocacy as well as educational missions.

The Journal of Pediatric Pharmacology and Therapeutics website

Position statements. PPA offers therapeutic position statements that respond to specific therapeutic issues. These statements are thorough, evidence-based recommendations of drug use. PPAG also offers position statements on public policy issues that are directed to health care professionals, public officials, and the general public.

PPA Position Statements page